Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. PRP is a conglomeration of thrombocytes, cytokines and various growth factors which are secreted by α-granules of platelets that augment the rate of natural healing process with decrease in time.

In a comprehensive analysis of the effect of PRP on wound healing we identified a key role of PRP in the three important stages of wound healing. It strongly enhances re-epithelialization, induces angiogenesis and is also involved in wound contraction and collagen deposition. Although there are still some molecular mechanisms to be explored in depth, studies support the use of PRP as an adjuvant to boost wound healing.